![]() ![]() The most well-characterized product of this reaction is phosphatidylinositol-3,4,5-trisphosphate or PIP 3, a critical second messenger that recruits AKT for activation of growth, proliferation and survival signaling ( Cantley, 2002). Phosphoinositide 3-kinases (PI3Ks) belong to a conserved family of lipid kinases that phosphorylate the 3′-hydroxyl group of phosphoinositides.
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